I ran into this the other day, simply remove the DNS= line from your conf.

Probably should be documented that wg-quick will barf and tear down your interface if you have DNS= but not `resolvconf` command.

On Fri, 1 Mar 2019 at 02:46, Reuben Martin <reuben.m.work@gmail.com> wrote:
On Thu, Feb 28, 2019, 12:29 PM F <finalcountdown@post.com> wrote:
Learnt how to get WG working here
https://github.com/StreisandEffect/streisand/issues/1434 and it
describes how the openresolv package is needed to get WG to connect

That may be a requirement in the context that document was written for. But that is not a requirement for wireguard.
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